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GLP 1R, GIPR, and GCGR: Targets for Obesity and Diabetes Sino Biological GLP 1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome PFKFB3 driven glycolysis interaction and histone lactylation Journal of Translational Medicine Springer Nature Link GNC Introduces Semaglutide Support Program: Holistic Solutions for GLP 1 Users GLP ONE Activator Bundle GLP ONE Supplements Results RNA, GLP 1 Advanced Metabolic Extra Strength Support Healthy Weight Management Agape Nutrition Gut inflammation in mice is alleviated by glucose dependent insulinotropic polypeptide receptor
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Best in 7 days
Best in 7 days
Best in 7 days
Best in 7 days
4.4 ★★★★★
Based on 869 reviews
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Product Reviews
★★★★★ 5
Gave me hope again for my back acne
Size: 5.5 Ounce (Pack of 1)
I’ve been struggling with acne on my back since I was a teen and I’m now in my 30s and still struggling. I had taken accutane (several times) and it was the only thing that has cleared me but it always came back. I decided that I’m not gonna risk potentially hurting myself over that medication again and consistently (no matter if I didn’t feel like it!) started washing my back with this every night (even if I didn’t wash my hair). I would leave it on for at least 5 minutes and then rinse it off, then moisturize. After a month this has been the CLOSEST to clear my skin has ever gotten besides accutane. I’ve tried virtually everything. I was honestly surprised, and although it’s not perfectly clear, it’s made a significantttttt difference. It’s worth a try if you plan to be serious about it. I wish I would have taken a before picture, I just didn’t have high expectations at first!!
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Reviewed in the United States on April 5, 2026
★★★★★ 4
Can do wonders but also can completely strip your healthy skin barrier
Size: 5.5 Ounce (Pack of 1)
Awesome product ONLY IF YOU HAVE SEVERE BREAKOUTS AND OILY SKIN. STAY AWAY IF YOU HAVE SLIGHTLY DRY SKIN AND/OR MINOR BREAKOUTS- not worth the risk.
I used it for back acne and it really helped. DO NOT MIX WITH OTHER ACNE PRODUCTS.
But HUGE HUGE HUGE HUGE WARNING!!!!!——
This is NOT a great play for your face or truly anyone who doesn’t have severe acne and oily skin. Yes, it eliminates acne. If your face is extremely oil and acne prone, every few days would be fine.
I, myself, always thought my face was a mix of oily and dry- but I had a lot of hormonal acne from birth control. At first, I would use this every few days (every other, every 3, depending), and I noticed it improving my facial acne as well. I used it for 3+ months. THEN *TRIGGER WARNING* I suddenly one day broke out in HIVES. It completely STRIPS YOUR SKIN BARRIER IF YOU OVERUSE IT OR IF YOUR SKIN IS NOT SEVERELY BROKEN OUT. Red, swollen, bumps, all over my face for a week straight. My face burned so bad I couldn’t even cry it hurt. I couldn’t sleep good. Couldn’t touch my face. Couldn’t even put on moisturizer. Not even an ice pack helped. I had to stop hot showers and every single facial product/makeup for multiple weeks to heal my face. I noticed after I stopped using it, it almost made my acne better on my face- like it truly did strip my skin barrier. I will no longer be putting this on my face UNLESS I have severe acne breakouts, and if that is the case it would be a ONE TIME use. I also DO NOT use it everyday on my back or chest, it’s more of an every other- every few days type of deal.
BE ADVISED- does the job, but can also make things worse.
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Reviewed in the United States on April 1, 2026
★★★★★ 5
This is a great product!
Size: 5.5 Ounce (Pack of 1)
Edit: bleached a bunch of our towels so just be aware of that. I never understood that bc he obviously rinses it all off. But it’s definitely 100% what caused the bleaching. It’s still a good product. You just have to delegate certain towels for the person using it.
My husband uses this in addition to Bubbles anti breakout facial cleanser. They have different types of ingredients (bubbles has salicylic acid) and work well together. This combo is working well for him. He has very oily skin on his face and head. He’s also been occasionally using a facial wipe during the day (when he thinks of it) for an extra quick cleaning.
We tried several different types of cleansers and he does also sometimes use a jojoba oil cleanser before the panoxyl and bubbles. (Oil breaks down oil. Despite it sounding like it would add greasiness, it does not. Jojoba oil balances all skin types and is noncomedogenic)
This product may be enough for most of you (it’s really good!) but just wanted to mention this for anyone else who struggles with really oily skin. Of note, he doesn’t ever get acne all over his face but gets an occasional medium to large oily pimple.
I also have him exfoliating once a week with Glycolic acid) and using Tretinoin a couple of times a week. He’s supposed to be working up to 3-4 times a week but forgets.
I’m a nurse who is wound care certified so know a lot about skin and really look at ingredients and research them. I’ve also worked for a dermatologist. However, please don’t take this as advice but a suggestion to bring up to your own dermatologist or doctor. :)
I suspect when he gets up to using Tretinoin more regularly he won’t even need anything else and it will keep him from breaking out altogether.
Good luck! Don’t forget sunscreen! :)
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Reviewed in the United States on May 10, 2026
★★★★★ 5
HOLY GRAIL PRODUCT!!!!!
Size: 5.5 Ounce (Pack of 1)
Don’t let the “unaesthetic” brand & packaging fool you— there is nothing better for acne than this face wash.
I have been repurchased this face wash for almost 10 years now. I use it morning & night for acne & use it daily on my armpits for a detox. I have combination skin, so this knocks out my greasy areas & acne, & then I just go in with a heavy duty moisturizer, barrier serum & milky toner after for my dry areas.
(Side note: I used Accutane as a 16 year old for cystic back acne & a face full of tiny white zits, & this has allowed me to maintain acne free skin almost 10 years later without getting a prescription ointment.)
As for consistency & smell: It’s a white cream that doesn’t foam, & a little goes a long way. One bottle last a RIDICULOUSLY long time, unlike most “viral” face washes that last a month. It doesn’t have any added fragrance, but still smells very clean (almost like a light chlorine, which I personally love).
As for cost: It’s also priced at an EXTREMELY low cost, with Walmarts great value version only being $0.50 less expensive for a more grainy & chemically smelling wash.
!!!!!!!ADDED WARNING!!!!!: this is a 10% benzoyl peroxide cream, which is REALLY strong. You absolutely need to ease your way into using it so you don’t give yourself a chemical burn, every other day to start AT LEAST, & beware of how long you leave it on your skin. I know people with severe cystic acne that will leave it on for minutes before washing it off, but I leave it on for 15 seconds MAX or else my face gets irritated. Beware of sun exposure, & be sure to research if it interacts with other skincare products you’re currently using!
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Reviewed in the United States on February 17, 2026
★★★★★ 5
Deeply cleans pores, helps reduce acne, and leaves the skin feeling fresh and smooth 💕
Size: 5.5 Ounce (Pack of 1), Size: 5.5 Ounce (Pack of 1)
⭐️⭐️⭐️⭐️⭐️
PanOxyl has really helped improve my skin! It deeply cleans my pores, helps reduce breakouts, and leaves my skin feeling fresh and smooth. I also noticed my acne started calming down after consistent use. Great product for acne-prone skin! 💕
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Reviewed in the United States on May 19, 2026
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